Inside Back Cover: Large‐Diameter DNA‐Scaffolded Nanopores Enabled by Loosely Packed Peptides for Single‐Molecule Sensing (Angew. Chem. Int. Ed. 29/2026)

Abstract

Nanopores serve as sensors for single-molecule characterization. In Research Article e3311099, Ryuji Kawano and co-workers constructed synthetic nanopores using DNA and peptides that enable single-molecule translocation. The cover illustrates that the key to pore formation is the presence of 2-aminoisobutyric acid in the peptide, while the DNA scaffold assembles the peptides into well-defined oligomeric states. Image credit: Hiroko Uchida.