Integration of Generative Protein Design with Synthetic Porphyrin Assembly: Metal‐Responsive Cyclic Assembly of a Bi‐Porphyrin Acquisition Designer Protein (Small 49/2025)

Abstract

Protein Design Generative protein design meets synthetic porphyrin assembly to yield a metal-responsive cyclic protein assembly, highlighting the synergy of protein engineering and synthetic chemistry. By fusing α/β-folded porphyrin-binding motifs, the de novo designed protein captures two synthetic porphyrins bearing an additional metal coordination site, resulting in a metal-triggered cyclic assembly and dynamic structural transformations. More in article number 2505625, Takayuki Uchihashi, Osami Shoji, and co-workers.